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картинка: A_Clinical_Guide_to_Stem_Cell_and_Bone_Marrow_Transplantation_The_Jones_and.jpg
Shapiro T.W., Davison D.B., Rust D.M.
Jones and Bartlett Publishers; 1997; 454стр.; ISBN: 076370217X

Book Description

...bone marrow transplantation clinicians can use this handbook for bedside use...includes information on symptom management, pre-transplant evaluation, and long-term follow up.




Book Info

Univ. of Arizona,Tucson.Pocket-sized, quick reference in outline format. Practical handbook for clinicians working with adult and pediatric bone marrow transplantation patients. Trim size: 6 x 4 inches.
/ Книги,  #91531  /
Область: другое
Язык и уровень: Специальный (анг)
Где взять: Было в сети
К началу страницы      Благодарностей за сообщение: 7 // FACSorter, kolbo, vikdent, medgun, Мурад, virokdezso, deniuscas       04.05.06  Baudelaire        комментарии: 0
картинка: A_Guide_to_Pharmaceutical_Particulate_Science.jpg   Оглавление книги
Crowder T.M., Hickey A., Louey M.D., Orr N.
CRC Press; 2003; 256стр.; ISBN: 1574911422

ISBN-13: 9781574911428

To buy:

http://www.amazon.com/exec/obidos/ASIN/1574911422/
http://search.barnesandnoble.com/booksearc...11422&pdf=y&z=y

Review
[This book] treats … various topics … in a logical sequence. The references are extensive and provide the reader with valuable guidance to the relevant literature, especially in the pharmaceutical sciences. … [T]his book provides an excellent foundation for a didactic course in particulate science or powder technology. … [It] will likewise be valuable to scientists who are eager to acquire basic knowledge of particulate science in pharmaceutics. - Pharmaceutical ResearchA useful guide to the subject…the volume covers a gap in the existing literature and should be on the shelves of company libraries.- Organic Process Research and Development Journal

Book Description
Exploring the growth in knowledge of particle properties and the variety of technological advances in particle manufacture, this book gives readers the tools they need to understand particulate science and its use in the industry. The authors cover particulate material, its form and production, sampling from bodies of powder, particle size descriptors and statistics, behavior of particles, instrumental analysis, particle size measurement and synergy of adopted techniques, physical behavior of a powder, and in vitro and in vivo performance criteria. They draw the components of particulate science into a single concise description of their integration in the context of product development.

From the Publisher
The pharmaceutical applications of powder technology have long been recognized. Yet while many books focus on aspects of powder formation and behavior, there has been no text that explores the power of particulate science in the design, manufacture, and control of quality medicines. Until now. A Guide to Pharmaceutical Particulate Science discusses key principles of particulate science and their practical applications. The authors cover particulate material, its form and production, sampling from bodies of powder, particle size descriptors and statistics, behavior of particles, instrumental analysis, particle size measurement and synergy of adopted techniques, physical behavior of a powder, and in vitro and in vivo performance criteria. They draw the components of particulate science into a single concise description of their current and potential uses in product development. Exploring the growth in knowledge of particle properties and the variety of technological advances in particle manufacture, A Guide to Pharmaceutical Particulate Science gives readers the tools they need to grasp the science and its use in the industry.

[/b]
This guide covers the principles of powder formation and behavior and its use in a wide range of pharmaceutical applications. The chapters cover particulate material form and production, sampling from bodies of powder, particle size descriptors and statistics, behavior of particles, instrumental analysis, particle size measurement and synergy of adopted techniques, physical behavior of powder, and in vitro and in vivo performance criteria. A comprehensive list of references is provided. The four authors hold PhDs in either pharmaceutical science or biomedical engineering. Annotation ©2003 Book News, Inc., Portland, OR
/ Книги,  #119010  /
Область: Фармацевтическая промышленность, Фармакология
Язык и уровень: Специальный (анг)
Где взять: Было в сети
К началу страницы            15.09.06  musand        комментарии: 0
картинка: A_Handbook_of_Bioanalysis_and_Drug_Metabolism.jpg   Оглавление книги
Ред. Evans G.
CRC Press; 2004; 416стр.; ISBN: 0415275199

ISBN-13: 9780415275194

To buy:

http://www.amazon.com/exec/obidos/ASIN/0415275199/
http://search.barnesandnoble.com/booksearc...75199&pdf=y&z=y

Book Description
This stimulating new handbook examines the techniques, methodology, and theory of bioanalysis and drug metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. It covers topics such as high performance liquid chromatography, protein binding, pharmacokinetics and drug-drug interactions. A Handbook of Bioanalysis and Drug Metabolism is an invaluable guide for senior undergraduates and postgraduates studying drug metabolism in courses such as pharmaceutical science, pharmacology, chemistry, physiology and toxicology - especially those considering industrial placements or a career in the biotechnology industry.

Book Info
Examines the techniques, methodology, and theory of bioanalysis, pharmacokinetics, and metabolism for researchers in the pharmaceutical industry. Covers such topics as physicochemical properties of drugs, sample preparation, high performance liquid chromatography, immunoassay, protein binding, isotope drug studies, and more. For senior undergraduates or postgraduates.

From the Publisher
Recent years have seen a greater industrial emphasis in the composition of undergraduate and postgraduate courses in the pharmaceutical and chemical sciences. However, textbooks have been slow to adapt, leaving cohorts of students without a reference text to take into the industrial setting -- until now. This stimulating new handbook examines the techniques, methodology, and theory of bioanalysis, pharmacokinetics, and metabolism from the perspective of scientists working in research and development in the pharmaceutical industry. The aim is to provide a bridge between introductory principles and professional training. Each chapter has been written by contributors who have extensive experience working in drug discovery and development and have specialist knowledge of the individual topics. A Handbook of Bioanalysis and Drug Metabolism is an invaluable reference to senior undergraduates and postgraduates studying drug metabolism in courses such as pharmaceutical science, pharmacology, chemistry, physiology, and toxicology -- especially those considering industrial placements. They will find the unique industrial perspective helps reinforce the theory and develop valuable analytical and interpreting skills. This book was written as a dedication to Grieves Harnby.

Synopsis
An invaluable guide for pharmacology students and professionals which will help to reinforce the theory in the subject of drug metabolism, and help develop valuable analytical and interpreting skills.

Rating
3 Stars from Doody
/ Книги,  #119011  /
Область: Фармацевтическая промышленность, Фармакология
Язык и уровень: Специальный (анг)
Где взять: Было в сети
К началу страницы      Благодарностей за сообщение: 1 // georgemihov       15.09.06  musand        комментарии: 2
картинка: A_Ph_D_Is_Not_Enough_A_Guide_to_Survival_in_Science.jpg
Feibelman P.J.
Addison-Wesley and Benjamin Cummings; 1994; 109стр.; ISBN: 0201626632

Book Info

Offers sound advice on selecting a thesis or postdoctoral adviser, choosing among research jobs in academia, government laboratories, and industry, preparing for an employment interview, and defining a research program. DLC: Science - Vocational guidance.
--This text refers to an out of print or unavailable edition of this title.
/ Книги,  #119865  /
Область: другое
Язык и уровень: Специальный (анг)
Где взять: Было в сети
К началу страницы      Благодарностей за сообщение: 6 // trundec, Brom, Sergiy Shemet, deniuscas, AlenaKashina, StadtN       20.09.06  Baudelaire        комментарии: 5



A Student Handbook for Writing in Biology, Third Edition
Knisely, Karin

http://ebooks.bfwpub.com/knisely3e.php
/ Книги,  #533257  /
Область: другое
Язык и уровень: другое
Где взять: Электронная версия
К началу страницы            27.08.13  tamo        комментарии: 0



A user's guide to the human genome; Nature Genetics supplement
Tyra G Wolfsberg, Kris A Wetterstrand, Mark S Guyer, Francis S Collins & Andreas D Baxevanis
Nature Publishing Group/Macmillan Online Publishing; 2002; pp82

The primary aim of A User’s Guide to the Human Genome is to provide the reader with an elementary hands-on guide for browsing and analyzing data produced by the International Human Genome Sequencing Consortium and other systematic sequencing efforts. The majority of this supplement is devoted to a series of worked examples, providing an overview of the types of data available, details on how these data can be browsed, and stepby- step instructions for using many of the most commonly-used tools for sequence-based discovery. The major web portals featured throughout include the National Center for Biotechnology Information Map Viewer, the University of California, Santa Cruz Genome Browser, and the European Bioinformatics Institute’s Ensembl system, along with many others that are discussed in the individual examples. It is hoped that readers will become more familiar with these resources, allowing them to apply the strategies used in the examples to advance their own research programs.
A user's guide to the human genome; Nature Genetics supplement
Tyra G Wolfsberg, Kris A Wetterstrand, Mark S Guyer, Francis S Collins & Andreas D Baxevanis
Nature Publishing Group/Macmillan Online Publishing; 2002; pp82

http://rapidshare.de/files/3544342/A_user_...genome.pdf.html
/ Литература,  #29715  /
Область: другое
Язык и уровень: Специальный (анг)
Где взять: Личная эл. библиотека
К началу страницы      Благодарностей за сообщение: 2 // Mitrofan, Gepard_M       01.08.05  afanasev-max        комментарии: 1
картинка: Absorption_and_Drug_Development_Solubility_Permeability.jpg
Avdeef A.
2003; 312стр.; ISBN: 0471423653

Review
“...a useful book for anyone interested in the measurement of physiochemical parameters that relate to drug permeability.”(Journal of Medicinal Chemistry, Vol. 47, No. 7) "...useful compilations of data...of use to those working in the agrochemical and environmental industries..." (Chemistry & Industry, 19 January 2004)

Review
“...a useful book for anyone interested in the measurement of physiochemical parameters that relate to drug permeability.”(Journal of Medicinal Chemistry, Vol. 47, No. 7) "...useful compilations of data...of use to those working in the agrochemical and environmental industries..." (Chemistry & Industry, 19 January 2004)

[b]


http://rapidshare.de/files/3544416/Absorpt...opment.pdf.html
/ Литература,  #29716  /
Область: другое
Язык и уровень: Специальный (анг)
Где взять: Было в сети
К началу страницы            01.08.05  afanasev-max        комментарии: 0
картинка: Absorption_and_Drug_Development_Solubility_Permeability_and_Charge_State.jpg   Оглавление книги
Avdeef A.
John Wiley & Sons; 2003; 312стр.; ISBN: 0471423653

Of the hundreds of thousands of compounds synthesized each year, most have almost no chance of becoming drugs. This problem exists because most molecules lack eht drug-like poperties necessary to enable them to be effective in vivo. To address this issue, Alex Avdeef’s Absorption and Drug Development shows the reader how to examine a compound’s pharmaceutical properties, emphasizing oral absorption. This book explains the different physiochemical methods currently used to analyze drug candidates and how to interpret these methods. Topics discussed include:
  • The physicochemical needs of pharmaceutical research and development
  • The flux model in terms of solubility, permeability, and charge state (pH)
  • Ionization constants
  • Experimental methods of measuring partition coefficients, log P and log D
  • Partition coefficients where the lipid phase is made of liposomes formed from vesicles of bilayers of phospholipids
  • PAMPA (parallel artificial membrane permeability assays)

Also included are physicochemical data for over 200 commercial drugs. With over 600 references and 100 drawings, this book is suitable for the practical pharmaceutical chemist and those seeking a better understanding of physiochemical measurements.
/ Литература,  #19234  /
Область: Биомедицина и Разработка лекарств, Фармацевтическая промышленность, Фармакология
Язык и уровень: Специальный (анг)
Где взять: Было в сети
К началу страницы            26.05.05  Redactor        комментарии: 0
картинка: Active_Oxygen_in_Chemistry_v2.jpg
Ред. Foote C.S.
Blackie Academic & Professional; 1995; 342стр.; ISBN: 0751402923

Book Description

Taking an interdisciplinary approach, this book and its counterpart, Active Oxygen in Biochemistry, explore the active research area of the chemistry and biochemistry of oxygen. Complementary but independent, the two volumes integrate subject areas including medicine, biology, chemistry, engineering, and environmental studies.

Book Info

Explores the active research area of the chemistry and biochemistry of oxygen. Surveys oxidation activation in key biological systems.
/ Книги,  #191319  /
Область: Молекулярная биология (биохимия, генная инженерия), Биофизика, Физиология (растений и животных), Биомедицина и Разработка лекарств, Биологические методы и инструменты, Экология и Окружающая среда, Органическая химия, Физическая химия, Биотехнология, Фармацевтическая промышленность
Язык и уровень: Специальный (анг)
Где взять: Было в сети
К началу страницы      Благодарностей за сообщение: 3 // uta, Muntyan, Gex2       14.10.07  mvmal        комментарии: 0
картинка: Active_Oxygen_in_Chemistry_Structure_Energetics_and_Reactivity_in_Chemistry.jpg
Ред. Foote C., Valentine J.S., Greenberg A., Liebman J.F.
Springer-Verlag; 1995; 360стр.; ISBN: 0412034417

Book Description

Taking an interdisciplinary approach, this book and its counterpart, Active Oxygen in Biochemistry, explore the active research area of the chemistry and biochemistry of oxygen. Complementary but independent, the two volumes integrate subject areas including medicine, biology, chemistry, engineering, and environmental studies.

Book Info

Explores the active research area of the chemistry and biochemistry of oxygen. Surveys oxidation activation in key biological systems.
--This text refers to the Hardcover edition.
/ Книги,  #191318  /
Область: Молекулярная биология (биохимия, генная инженерия), Биофизика, Физиология (растений и животных), Биомедицина и Разработка лекарств, Биологические методы и инструменты, Экология и Окружающая среда, Органическая химия, Физическая химия, Биотехнология, Фармацевтическая промышленность, Химическая промышленность
Язык и уровень: Специальный (анг)
Где взять: Было в сети
К началу страницы            14.10.07  mvmal        комментарии: 1
картинка: Active_Pharmaceutical_Ingredients_Development_Manufacturing_and_Regulation.jpg   Оглавление книги
Ред. Nusim S.
Marcel Dekker; 2005; 368стр.; ISBN: 082470293X

ISBN-13: 9780824702939

To buy:

http://www.amazon.com/exec/obidos/ASIN/082470293X/
http://search.barnesandnoble.com/booksearc...0293X&pdf=y&z=y

Book Description
Focusing on the three most critical components that successfully bring an API to market-process development, manufacturing, and governmental regulation and approval-this reference serves as a step-by-step guide to the planning and clear understanding of the bulk manufacturing of APIs. It offers current and timely discussions of the process development cycle, design engineering, the approval process, quality control and assurance, and validation, as well as plant manufacturing activities including materials management, maintenance, and safety. Filling a gap in the literature, this guide covers all the essential information required to effectively plan and execute manufacturing APIs.
/ Книги,  #115647  /
Область: Фармацевтическая промышленность, Фармакология
Язык и уровень: Специальный (анг)
Где взять: Было в сети
К началу страницы            29.08.06  musand        комментарии: 1
картинка: Active_Pharmaceutical_Ingredients.jpg   Оглавление книги
Drugs and the Pharmaceutical Sciences
Nusim S.
Marcel Dekker, Inc.; 2005; 368стр.; ISBN: 082470293X

Book Description

Focusing on the three most critical components that successfully bring an API to market-process development, manufacturing, and governmental regulation and approval-this reference serves as a step-by-step guide to the planning and clear understanding of the bulk manufacturing of APIs. It offers current and timely discussions of the process development cycle, design engineering, the approval process, quality control and assurance, and validation, as well as plant manufacturing activities including materials management, maintenance, and safety. Filling a gap in the literature, this guide covers all the essential information required to effectively plan and execute manufacturing APIs.

To buy:
http://www.amazon.com/exec/obidos/ASIN/082470293X/
/ Книги,  #163771  /
Область: Биомедицина и Разработка лекарств, Научные исследования (другое), Фармацевтическая промышленность, Индустрия (другое)
Язык и уровень: Специальный (анг)
Где взять: Было в сети
К началу страницы      Благодарностей за сообщение: 1 // CowDoc       25.04.07  goddan        комментарии: 1
картинка: Aerosols_Handbook_Measurement_Dosimetry_and_Health_Effects.jpg   Оглавление книги
Ruzer L.S., Harley N.H.
CRC Press; 2004; 728стр.; ISBN: 1566706114

Book Description

Increased attention on the occupational health risks associated with the industrial manufacture and use of nanotechnology make this presentation of the latest research in the field of aerosol science extremely timely. The book covers indoor, outdoor, and industrial aerosols, including aerosol measurement, deposition, particle size distribution, and biokinetic processes. The book covers all relevant aspects of aerosols, from epidemiology to molecular biology, and emphasizes the importance of accurate aerosol measurement. The authors discuss the effects of radioactive aerosols and focus on the health effects of specific aerosols, such as diesel aerosols and ultrafine particles.

To buy:
http://www.amazon.com/exec/obidos/ASIN/1566706114/
http://www.crcpress.com/
/ Книги,  #165712  /
Область: Молекулярная биология (биохимия, генная инженерия), Биология (другое), Физика, Научные исследования (другое), Фармацевтическая промышленность
Язык и уровень: Специальный (анг)
Где взять: Было в сети
К началу страницы            05.05.07  goddan        комментарии: 1
картинка: An_Introduction_to_Genetic_Analysis.jpg
Suzuki D.T., Lewontin R.C., Wessler S.R.
2004; 800стр.; ISBN: 0716749394

For nearly three decades, from edition to edition, An Introduction to Genetic Analysis (IGA) has evolved side by side with genetic research, providing an experiment-based introduction to fundamental concepts that reflects every major laboratory and conceptual breakthrough. With authors who are leading researchers, innovative educators, and acclaimed writers, the book has kept pace with the dramatic expansion of the field while finding better ways to help students learn how to put genetics concepts to work.

Now the text that has been used by over three-quarters of a million students returns in the most extensively revised new edition in the book's history, once again shaping its coverage to match current research and thinking in genetics while providing stronger pedagogical support. The edition features a new coauthor Susan R. Wessler (a member of the National Academy of Sciences), dramatic new content and art, reorganized structure, new learning tools, and state-of-the-art media and supplements, making it the ideal text for preparing today's students for tomorrow's genetics.

Link: http://rapidshare.de/files/3545137/An_Intr...s__8th.pdf.html
/ Литература,  #29725  /
Область: другое
Язык и уровень: Специальный (анг)
Где взять: Было в сети
К началу страницы      Благодарностей за сообщение: 4 // Mitrofan, osaamaa, uta, OTK       01.08.05  afanasev-max        комментарии: 0
картинка: Analysis_Surfactants_Surfactant.jpg   Оглавление книги
Surfactant Science Series
Schmitt T.M.
CRC Press; 2001; 635стр.; ISBN: 0824704495

From publisher

# Describes the makeup and structural drawings for an array of commercial surfactants
# Presents the accepted methodology for determining active agents and impurities in surfactants, for quality control and particular problems
# Discusses spectroscopic and chromatographic methods of characterization and concentration used in the analytical chemistry of surfactants
# Reviews techniques for identifying surfactants in the environment, including impurities and degradation products like nonylphenol and alkylbenzenes
# Examines formulated cleaning products for the most cost-effective solutions in specific situations
# Provides guidelines for comparing the claims of instrumentation manufacturers


In the tradition of the popular first edition, Analysis of Surfactants, Second Edition offers a comprehensive and practical account of analysis methods for determining and understanding commercially important surfactants-individually and in compounds. Combining a complete review of the literature with a variety of evaluation procedures and the specifications for commercial products, this useful reference explores the key stages and latest developments for surfactant applications. This edition has been thoroughly expanded and features new sections on capillary electrophoresis, ether carboxylates, and ester quats. It is also more globally accessible with foreign language citations and SI units.

Containing over 2400 references, drawings, tables, and equations, Analysis of Surfactants, Second Edition is an recommended reference for physical, surface, colloid, and oil chemists; analytical, research, and quality assurance chemists working in the soap and detergent, pharmaceuticals, and cosmetic industries; regulatory and food scientists; and upper-level undergraduate and graduate students in these disciplines.

To buy:
http://www.amazon.com/exec/obidos/ASIN/0824704495/
http://www.crcpress.com/
/ Книги,  #158417  /
Область: Биомедицина и Разработка лекарств, Аналитическая химия, Физическая химия, Другая химия, Фармацевтическая промышленность
Язык и уровень: Специальный (анг)
Где взять: Было в сети
К началу страницы            01.04.07  goddan        комментарии: 1
картинка: Animal_Biotechnology_Science-based_Concerns.jpg   Оглавление книги
Ред. Davis D.
National Academies Press; 2002; 201стр.; ISBN: 0309084393

Genetic-based animal biotechnology has produced new food and pharmaceutical products and promises many more advances to benefit humankind. These exciting prospects are accompanied by considerable unease, however, about matters such as safety and ethics. This book identifies science-based and policy-related concerns about animal biotechnology—key issues that must be resolved before the new breakthroughs can reach their potential.

The book includes a short history of the field and provides understandable definitions of terms like cloning. Looking at technologies on the near horizon, the authors discuss what we know and what we fear about their effects—the inadvertent release of dangerous microorganisms, the safety of products derived from biotechnology, the impact of genetically engineered animals on their environment. In addition to these concerns, the book explores animal welfare concerns, and our societal and institutional capacity to manage and regulate the technology and its products. This accessible volume will be important to everyone interested in the implications of the use of animal biotechnology.
/ Литература,  #19269  /
Область: Пищевая промышленность и Диетология, Биотехнология, Фармацевтическая промышленность
Язык и уровень: Популярный (анг), Высшая школа (анг)
Где взять: Было в сети
К началу страницы            26.05.05  Redactor        комментарии: 2
картинка: Animal_Cell_Culture_A_Practical_Approach.jpg
Ред. Masters J.R.
Oxford University Press; 2000; 315стр.; ISBN: 0199637970

Book Info
Univ. College London, UK. Covers fundamental material, including basic principles, serum-free culture, characterization and authentication. Also includes topics such as tissue engineering, apoptosis assays and cytotoxicity assays, FISH, and stem cell assays. For researchers. Previous edition: c1992. Hardcover, softcover also available.

Link: http://rapidshare.de/files/3580694/Animal_...proach.pdf.html
/ Литература,  #29908  /
Область: другое
Язык и уровень: Специальный (анг)
Где взять: Было в сети
К началу страницы      Благодарностей за сообщение: 9 // Baudelaire, Cells-nnm, tissengineer, OTK, ветеринар, CowDoc, Raiboww, DaDa-Bu, StadtN       02.08.05  afanasev-max        комментарии: 5
картинка: Antisense_Drug_Technology_Principles_Strategies_and_Applications.jpg   Оглавление книги
Ред. Crooke S.T.
CRC Press; 2001; 929стр.; ISBN: 0824705661

From publisher

This state-of-the-art reference provides comprehensive coverage of the development of antisense oligonucleotides to inhibit cancer cells as well as those involved in infectious, inflammatory, and immune-mediated diseases-highlighting new tools and technologies in medicinal chemistry, RNA biochemistry, and molecular and cellular biology to produce new therapeutic compounds.Presents previously unpublished data on the use of antisense technology to dissect pharmacological processes and confirm the roles of various genes!Showcasing the benefits of antisense drug use, including reduced toxicity and earlier disease detection, Antisense Drug Technology discussesnovel formulations of antisense drugspractical methods to design effective isotype selective inhibitorsmolecular mechanisms of antisense drugsmRNA as a current biological templatemodern postreceptor binding mechanismsand more!With contributions by over 60 seasoned experts in the field and containing more than 3000 helpful references, tables, drawings, and photographs, Antisense Drug Technology is an illuminating source for organic, medicinal, and pharmaceutical chemists; biochemists; geneticists; hematologists; oncologists; molecular and cell biologists; virologists; immunologists; and medical school and graduate students in these disciplines.

To buy:

http://www.amazon.com/exec/obidos/ASIN/0824705661/
http://www.crcpress.com/

Book Info

Isis Pharmaceuticals, Inc., Carlsbad, CA. Reference provides comprehensive coverage of the development of antisense oligonucleotides to inhibit cancer cells and those involved in infections, inflammatory, and immune-mediated diseases. Highlights new tools and techniques in medicinal chemistry, RNA biochemistry, and molecular and cellular biology.
/ Книги,  #125210  /
Область: Микробиология (бактериология, вирусология, микология), Биология развития и Клеточная биология (иммунология, гистология, нейробиология), Молекулярная биология (биохимия, генная инженерия), Научные исследования (другое), Фармацевтическая промышленность, Фармакология
Язык и уровень: Специальный (анг)
Где взять: Было в сети
К началу страницы            16.10.06  goddan        комментарии: 2
картинка: Antiviral_Drug_Discovery_for_Emerging_Diseases_and_Bioterrorism_Threats.jpg
Ред. Torrence P.F.
John Wiley & Sons; 2005; 420стр.; ISBN: 0471668273

Book Description
Antiviral Drug Discovery gives readers a cutting-edge view of how chemical concepts are being mobilized to develop novel approaches that will effectively confront emerging diseases and biowarfare. Among the many topics discussed are smallpox, the Ebola virus, influenza, SARS, arenaviruses and flaviviruses. Each chapter discusses hypothetical strategies for the discovery of relevant antiviral agents, recent findings related to biochemistry or drug discovery, and advances in the further development of established leads in the area. Timely and informative, this book clearly delineates the efforts being made to develop new and effective broad-spectrum antiviral agents.

From the Back Cover
Promising drug discovery efforts in the race to cure emerging diseases and thwart bioterrorism It was not too long ago that scientists believed that the discovery of powerful antimicrobial agents and vaccines would lead to the eradication of viral diseases. A warning, however, of the looming threat of viral diseases on U.S. national security was sounded in the 2000 National Intelligence Estimate, The Global Infectious Disease Threat and Its Implications for the United States. This report predicted that infectious diseases would endanger U.S. citizens at home and abroad, threaten U.S. forces deployed overseas, and exacerbate social and political instability. In the post-9/11 world, we can clearly see the gravity of those predictions, which greatly underscore the need for this timely publication. This is the first book that tackles head-on the myriad viral threats for which no effective drug treatments currently exist. Among the threats covered are potential bioterrorism agents and emerging viruses such as smallpox, influenza, Ebola, Marburg, SARS, Nipah, Hendra, Lassa fever, Junin, dengue, West Nile, and yellow fever. The editor of this publication has assembled an international team of leading experts, giving readers a cutting-edge view on current drug discovery efforts to find novel antiviral agents in the battle to combat these diseases and threats. Following a general introduction to the problems of emerging diseases and bioterrorism, each chapter discusses potential strategies for the discovery of antiviral agents, reveals recent findings, and points to promising directions for further research. Many of the contributors have honed their knowledge and offer unique insights based on their work with powerful viruses such as herpes and HIV. A variety of different strategies and targets are discussed in the ongoing exploration for effective treatment modalities. Specific targets of the virus's genomes and proteomes are presented as sources for antiviral agent prospectors. These include interferon evasion proteins, proteases, helicases, RNA polymerases, and methyl transferases. In addition, other targets presented are s-adenosylhomocystein hydrolase (SAH) and inosine monophosphate dehydrogenase (IMPDH). Generic approaches discussed include lethal mutagenesis, immunocamouflage, and prenylation inhibitors. Prodrugs and acyclic nucleoside monophosphates are among the antiviral countermeasures presented from the medicinal/bioorganic chemical arsenal. With so much at stake, the need to collect promising antiviral drug discovery strategies in one volume and disseminate it to all researchers in the field has never been greater. This is urgent reading for all researchers in medicinal chemistry, pharmaceutical chemistry, drug discovery, biochemistry, virology, microbiology, and public health. This publication can help them in their charge to protect the health of the world against the perilous threat of emerging infectious diseases and bioterrorism.







See all Editorial Reviews

/ Книги,  #62560  /
Область: другое
Язык и уровень: Специальный (анг)
Где взять: Было в сети
К началу страницы            19.12.05  Baudelaire        комментарии: 2
картинка: Assessing_Bioavailablility_of_Drug_Delivery_Systems_Mathematical_Modeling.jpg   Оглавление книги
Vergnaud J.M., Rosca I.D.
CRC Press; 2005; 248стр.; ISBN: 0849330440

Book Description

This book introduces mathematical modeling methods for calculating the profiles of plasma levels obtained with controlled release dosage forms and provides examples and case studies to illustrate the techniques employed. The mathematical models developed by the author are particularly powerful because they account for such major parameters as the kinetics of drug release controlled by diffusion or by erosion, and the kinetics of absorption into and elimination out of the plasma. They are also able to solve the problem of determining the drug level in plasma as a result of patient non-compliance, incorrect dosage, and incorrect frequency, and to determine the best dosage forms necessary for therapy.

To buy:
http://www.amazon.com/exec/obidos/ASIN/0849330440/
http://www.crcpress.com/
/ Книги,  #164563  /
Область: Фармацевтическая промышленность
Язык и уровень: Специальный (анг)
Где взять: Было в сети
К началу страницы            29.04.07  goddan        комментарии: 1
всего: 227   страницы (12):  1 2 3 4 5 > » 
 


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