Molbiol.ru | О проекте | Справочник | Методы | Растворы | Расчёты | Литература | Орг.вопросы Web | Фирмы | Coffee break | Картинки | Работы и услуги | Биржа труда | Zbio-wiki NG SEQUENCING · ЖИЗНЬ РАСТЕНИЙ · БИОХИМИЯ · ГОРОДСКИЕ КОМАРЫ · А.А.ЛЮБИЩЕВ · ЗООМУЗЕЙ Темы за 24 часа [ Вход* | Регистрация* ] Форум: | |
Guest IP-штамп: fr45uHVgO7WZ2 гость |
(Ъ @ 19.09.2007 11:48) Привет Не только божьих коровок и всяких там волбахий. Привет передать от тебя - это от меня через улицу? ну нафиг - похоже он с божих коровок на потомков Чингиз-Хана ll: 1 Review: 0 [Click to change filter selection through My NCBI.] 1: Genetika. 2007 Mar;43(3):422-6.Links [Distribution of the male lineages of Genghis Khan's descendants in northern Eurasian populations] [Article in Russian] Derenko MV, Maliarchuk BA, Wozniak M, Denisova GA, Dambueva IK, Dorzhu CM, Grzybowski T, Zakharov IA. Data on the variation of 12 microsatellite loci of Y-chromosome haplogroup C3 were used to screen lineages included in the cluster of Genghis Khan's descendants in 18 northern Eurasian populations (Altaian Kazakhs, Altaians-Kizhi, Teleuts, Khakassians, Shorians, Tyvans, Todjins, Tofalars, Sojots, Buryats, Khamnigans, Evenks, Mongols, Kalmyks, Tajiks, Kurds, Persians, and Russians; the total sample size was 1437 people). The highest frequency of haplotypes from the cluster of the Genghis Khan's descendants was found in Mongols (34.8%). In Russia, this cluster was found in Altaian Kazakhs (8.3%), Altaians (3.4%), Buryats (2.3%), Tyvans (1.9%), and Kalmyks (1.7%). PMID: 17486763 [PubMed - indexed for MEDLINE] |
grigoriev Moscow, Russia |
|
Guest IP-штамп: fr45uHVgO7WZ2 гость |
(Ъ @ 19.09.2007 11:48) Привет Не только божьих коровок и всяких там волбахий. Привет передать от тебя - это от меня через улицу? интересная у него публикация - вот кого на ДНК надо было : 1 Review: 0 [Click to change filter selection through My NCBI.] 1: Genetika. 1999 Oct;35(10):1317-21.Links [Demographic and genealogical study of Russian Academicians from 1846-1924. (Results of a study by I. A. Filipchenko and his colleagues) (on the 275-th anniversary of the Russian Academy of Sciences)] [Article in Russian] Zakharov IA. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia. The main results of the study on the membership of the Russian Academy of Sciences from 1846 to 1924 published by T.K. Lepin, Ya.Ya. Lus, and Yu.A. Filipchenko in 1925 are reviewed. These results include the ethnic and social backgrounds of the academicians, their life spans, family status, and the presence or absence of artistic or other special talents. The authors of the early study concluded that academicians of the Imperial Academy originated from all classes of society, most of them were university professors, and 77 out of 150 academicians had outstanding relatives who left a mark in the history of culture. PMID: 10624579 [PubMed - indexed for MEDLINE] |
Guest IP-штамп: fr45uHVgO7WZ2 гость |
(Ъ @ 19.09.2007 11:48) Привет Не только божьих коровок и всяких там волбахий. Привет передать от тебя - это от меня через улицу? Спроси -если с потомками Чингис-Хана маловато - может потомками Алксандра Македонского заняться |
Ъ IP-штамп: frNwv0U1khjS. гость |
|
Ъ IP-штамп: frNwv0U1khjS. гость |
|
Guest IP-штамп: fr45uHVgO7WZ2 гость |
(Ъ @ 19.09.2007 13:49) Но, пожалуй, лучшим консультантом может выступить Илья Арменьевич Захаров. Мне так кажется. мне усегда интересно было - как зависит скорость мутирования сперматозоидов от питания (канцерогенчики -мутагенчики) или проживания на урановом руднике ? ну зарасло зерно грибочками с мутагенными токсинчиками предки это даже и не знали - мутировали напропалую |
Guest IP-штамп: fr45uHVgO7WZ2 гость |
(Ъ @ 19.09.2007 13:42) Далее Рысков А.П. из Института Биологии гена РАн, Лимборская С.А. из Института молекулярной генетики РАН. Деренко Мирослава и Малярчук Борис очень автивно и давно работают в этой области (миграция северных народов), но они в Магадане. Далее Хуснидинова (по И.О.не знаю) из Уфы ... список можно продолжит из новой генерации. усетаки методы наверно улучшать нуно 1: Nat Genet. 2007 Sep 9; [Epub ahead of print]Click here to read Links Measurement of the human allele frequency spectrum demonstrates greater genetic drift in East Asians than in Europeans. Keinan A, Mullikin JC, Patterson N, Reich D. [1] Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA. [2] Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02139, USA. [3] These authors contributed equally to this work. Large data sets on human genetic variation have been collected recently, but their usefulness for learning about history and natural selection has been limited by biases in the ways polymorphisms were chosen. We report large subsets of SNPs from the International HapMap Project that allow us to overcome these biases and to provide accurate measurement of a quantity of crucial importance for understanding genetic variation: the allele frequency spectrum. Our analysis shows that East Asian and northern European ancestors shared the same population bottleneck expanding out of Africa but that both also experienced more recent genetic drift, which was greater in East Asians. PMID: 17828266 [PubMed - as supplied by publisher] |
Yuri K IP-штамп: frbSxBL61s/9I гость |
(Guest @ 19.09.2007 08:56) Юр - когда нету банка доноров костного мозга отсиквенированных в упор - заниматся такой фигней - аморально да и закона нету что частники могут иметь доступ к генетическому материалу россиян - пускай сначала в ФСБ прогуляется Welcome to Capitalism. |
Guest IP-штамп: fr45uHVgO7WZ2 гость |
(Yuri K @ 19.09.2007 18:17) Да уж - капитализм блин "Новый русский" с пачпортом , что он потомок Чингиз-Хана по половой хромосоме - бред |
error Постоянный участник 192.168.0.1 |
(Guest @ 19.09.2007 08:00) в р-не ЧАЭС частота соматических мутаций по STR вдвое выше средней по региону - сцылку дать не могу ибо запамятовал, но было давно и в Генетике
|
Ъ IP-штамп: frNwv0U1khjS. гость |
(error @ 19.09.2007 19:45) в р-не ЧАЭС частота соматических мутаций по STR вдвое выше средней по региону - сцылку дать не могу ибо запамятовал, но было давно и в Генетике Дубрава, но уже не в Генетике. |
Ъ IP-штамп: frNwv0U1khjS. гость |
(error @ 19.09.2007 19:45) в р-не ЧАЭС частота соматических мутаций по STR вдвое выше средней по региону - сцылку дать не могу ибо запамятовал, но было давно и в Генетике Не по STR, а по минисателлитам по Джефрису. Но результаты никто не воспроизвел на моделях.
|
genseq Постоянный участник |
(Ъ @ 19.09.2007 11:42) Хуснутдинова Эльза Камилевна |
Amanita Участник |
Сообщение было отредактировано Amanita - 20.09.2007 13:55 |
Guest IP-штамп: fr45uHVgO7WZ2 гость |
(Amanita @ 20.09.2007 13:53) Что вас конкретно интересует? Из более молодых имен - Олег Балановский, он как раз занимается славянами. ну и как ? славяне это славяне или не славяне у него по ДНК получается ? |
Guest IP-штамп: fr45uHVgO7WZ2 гость |
(Amanita @ 20.09.2007 13:53) Что вас конкретно интересует? Из более молодых имен - Олег Балановский, он как раз занимается славянами. немцы окружают 1: Ann Hum Genet. 2001 Jan;65(Pt 1):63-78.Click here to read Links Mitochondrial DNA variability in Russians and Ukrainians: implication to the origin of the Eastern Slavs. Malyarchuk BA, Derenko MV. Institute of Biological Problems of the North, Magadan, Russia. ibpn@online.magadan.su In order to investigate the origin of the Eastern Slavs, mitochondrial DNA (mtDNA) sequence variation was examined in Russians and Ukrainians by hypervariable segment I (HVS I) sequencing and restriction analysis of the haplogroup-specific sites. No significant differences were found for Russians and Ukrainians when compared to other Europeans - in fact, they fall within the range of gene diversity seen throughout Europe and exhibit the unimodal pattern of pairwise sequence differences. Moreover, HVS I sequences in the Russians and Ukrainians are similar or identical to those found in eastern and western European populations. Despite the small genetic distances between Europeans, phylogenetic analysis reveals a considerable heterogeneity of Eastern Slavonic populations - they do not cluster together onto a phylogenetic tree. Analysis of distribution of rare HVS I types shared between populations of Eastern Slavs and other West Eurasians has shown that Russians share rare haplotypes mainly with Germans and Finno-Ugric populations. Of these, subhaplogroup H1 sequence types, which are defined by different combinations of nucleotides 16192T, 16294T, 16304C, 16311C and 16320T, are found predominantly in common between Russians and German-speaking populations. The data obtained allow us to conclude that the Slavonic migrations in early Middle Ages from their putative homeland in central Europe to the east of Europe were accompanied mostly by the same mtDNA types characteristic for the pre-Slavonic populations of eastern Europe. PMID: 11415523 [PubMed - indexed for MEDLINE] |
Ъ IP-штамп: frNwv0U1khjS. гость |
и так далее ... Не нужны никакие опросы. Мнения ученых можно узнать из попсовых источников. Читайте и делайте выводы, знакомтесь с ними, заочно ... К сожалению, ни чем более помочь не могу. |
Guest IP-штамп: fr45uHVgO7WZ2 гость |
1: Nat Genet. 2007 Sep 16 Population genomics of human gene expression. Stranger BE, Nica AC, Forrest MS, Dimas A, Bird CP, Beazley C, Ingle CE, Dunning M, Flicek P, Koller D, Montgomery S, Tavaré S, Deloukas P, Dermitzakis ET. The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. Genetic variation influences gene expression, and this variation in gene expression can be efficiently mapped to specific genomic regions and variants. Here we have used gene expression profiling of Epstein-Barr virus-transformed lymphoblastoid cell lines of all 270 individuals genotyped in the HapMap Consortium to elucidate the detailed features of genetic variation underlying gene expression variation. We find that gene expression is heritable and that differentiation between populations is in agreement with earlier small-scale studies. A detailed association analysis of over 2.2 million common SNPs per population (5% frequency in HapMap) with gene expression identified at least 1,348 genes with association signals in cis and at least 180 in trans. Replication in at least one independent population was achieved for 37% of cis signals and 15% of trans signals, respectively. Our results strongly support an abundance of cis-regulatory variation in the human genome. Detection of trans effects is limited but suggests that regulatory variation may be the key primary effect contributing to phenotypic variation in humans. We also explore several methodologies that improve the current state of analysis of gene expression variation. PMID: 17873874 [PubMed - as supplied by publisher] |
Guest IP-штамп: fr45uHVgO7WZ2 гость |
а женский - на митохондриальной ДНК . |
Ъ IP-штамп: frNwv0U1khjS. гость |
(Guest @ 20.09.2007 19:12) впал в задумчивость - мужской русский генофонд поместился на Y - хромосоме , а женский - на митохондриальной ДНК . Не надо впадать. Это я не для тебя выставил. |
Guest IP-штамп: fr45uHVgO7WZ2 гость |
(Ъ @ 20.09.2007 19:17) зато свежачок из Нейча Генетикс - я для антрапологов из "русского генофонда" чтоб не думали что форму черепа сперматозоид одной маленкой хромосомой по наследству привет |
Guest IP-штамп: fr45uHVgO7WZ2 гость |
(Ъ @ 20.09.2007 19:17) так чото 500000 СНИПов на одно квадратное рыло - как минимум и уперед 1: Pharmacogenomics. 2006 Jun;7(4):641-8.Click here to read Links Whole-genome genotyping of haplotype tag single nucleotide polymorphisms. Gunderson KL, Kuhn KM, Steemers FJ, Ng P, Murray SS, Shen R. Illumina, Inc., 9885 Towne Centre Dr., San Diego, CA 92121, USA. kgunderson@illumina.com The International HapMap Consortium recently completed genotyping over 3.8 million single nucleotide polymorphisms (SNPs) in three major populations, and the results of studying patterns of linkage disequilibrium indicate that characterization of 300,000-500,000 tag SNPs is sufficient to provide good genomic coverage for linkage-disequilibrium-based association studies in many populations. These whole-genome association studies will be used to dissect the genetics of complex diseases and pharmacogenomic drug responses. As such, the development of a cost-effective genotyping platform that can assay hundred of thousands of SNPs across thousands of samples is essential. In this review, we describe the development of a whole-genome genotyping (WGG) assay that enables unconstrained SNP selection and effectively unlimited multiplexing from a single sample preparation. The development of WGG in concert with high-density BeadChips has enabled the creation of three different high-density SNP genotyping BeadChips: the Sentrix Human-1 Genotyping BeadChip containing over 109,000 exon-centric SNPs; the HumanHap300 BeadChip containing over 317,000 tag SNPs, and the HumanHap550 Beadchip containing over 550,000 tag SNPs. PMID: 16768648 [PubMed - indexed for MEDLINE] |
Ъ IP-штамп: frNwv0U1khjS. гость |
(Guest @ 20.09.2007 18:56) Nat Genet. 2007 Sep 16 Population genomics of human gene expression. Stranger BE, Nica AC, Forrest MS, Dimas A, Bird CP, Beazley C, Ingle CE, Dunning M, Flicek P, Koller D, Montgomery S, Tavaré S, Deloukas P, Dermitzakis ET. Не обязательно свежак, можно и залежавшуюся почитать, не вредно. |
Guest IP-штамп: fr45uHVgO7WZ2 гость |
(Ъ @ 20.09.2007 19:17) интересно было почитать болтунов про "русские гены" - которые не отсиквенировали даже геном одной бактерии |
Guest IP-штамп: fr45uHVgO7WZ2 гость |
(Ъ @ 20.09.2007 20:32) Не обязательно свежак, можно и залежавшуюся почитать, не вредно. |
Guest IP-штамп: fr45uHVgO7WZ2 гость |
(Ъ @ 20.09.2007 20:32) Не обязательно свежак, можно и залежавшуюся почитать, не вредно. |
grigoriev Moscow, Russia |
Не подскажете, что за работа Kivisild et al. 2006 в которой говорится о мтДНК филогенетическом древе? |
Amanita Участник |
|
grigoriev Moscow, Russia |
Мне интересна мт-гаплогруппа J*. Мне известны результаты тестирования: mtDNA: J* (069T,126C) Интересует, также - J1c. Посоветуйте наиболее стоящие статьи, пожалуйста. Если среди них будут и на русском языке - вообще здорово! |
Amanita Участник |
Это конечно 2004 год, но я думаю там полная библиография по J на то время. Вы дали свой ГВС, а дополнительные СНИпы были сделаны? В понеделеьник спрошу еще про статьй по этой гаплогруппе. |
Amanita Участник |
|
grigoriev Moscow, Russia |
|
grigoriev Moscow, Russia |
|
Guest1 Постоянный участник |
(Amanita @ 22.09.2007 19:23) Ну в общем в своей статье 2006 года Тоомас Кивисильд предложил новое время мутации для кодирующего региона мтДНК, одна мутация за примерно 6700 лет, учитываются только синонимичные транзиции, те мутации, кот. не приводят к изменению АК последовательности. Анализ был основан на порядка 200 полных мтДНК геномах, которыми были представелны все наиболее распространенные гаплогруппы и все регионы планеты. До этой статьи не было хороших часов для датировки на основе филогении полных мтДНК геномов. Статья Мишмар 2005 критиковалась, тк часы предложенные в ней использовали все мутации кодирующего региона, т.е. и те, кот. приводят к замене АК (несинонимичные). Такие мутации будут подвержены ест. отбору, они не будут отвечать молекулярным часам => возраст рассчитаный на их основе будет неверным. До этого использовалась датировка на основе некодирующей части мтДНА, Д-лооп, а точнее части ее ГВС–1 сегмента (хыпер вариабле сегмент 1). Скорость мутации была предложена Банделт 1996, и равнялась 1 транзиция за 20180 лет, эти данные были получены на основе анализа вариабельности мтДНК америндов. Если есть вопросы еще, спрашивайте, попробую ответит, но сразу оговорюсь, я по славянам да и вообще европе не спец. Моя специфика Ю, ЮВ Азия и Океания, Австралия. Но могу попробывать проконсультироваться у коллег. зависит ли хвр-1 от жителей в екологически грязных раёнах + мутагены в продуктах питания по сравнению с благополучными раэнами ? |
Guest IP-штамп: fr45uHVgO7WZ2 гость |
Review: 0 [Click to change filter selection through My NCBI.] 1: Mol Biol Evol. 2005 Jul;22(7):1561-8. Epub 2005 Apr 6.Click here to read Links Time dependency of molecular rate estimates and systematic overestimation of recent divergence times. Ho SY, Phillips MJ, Cooper A, Drummond AJ. Henry Wellcome Ancient Biomolecules Centre, Department of Zoology, University of Oxford, Oxford, United Kingdom. simon.ho@zoo.ox.ac.uk Studies of molecular evolutionary rates have yielded a wide range of rate estimates for various genes and taxa. Recent studies based on population-level and pedigree data have produced remarkably high estimates of mutation rate, which strongly contrast with substitution rates inferred in phylogenetic (species-level) studies. Using Bayesian analysis with a relaxed-clock model, we estimated rates for three groups of mitochondrial data: avian protein-coding genes, primate protein-coding genes, and primate d-loop sequences. In all three cases, we found a measurable transition between the high, short-term (< 1-2 Myr) mutation rate and the low, long-term substitution rate. The relationship between the age of the calibration and the rate of change can be described by a vertically translated exponential decay curve, which may be used for correcting molecular date estimates. The phylogenetic substitution rates in mitochondria are approximately 0.5% per million years for avian protein-coding sequences and 1.5% per million years for primate protein-coding and d-loop sequences. Further analyses showed that purifying selection offers the most convincing explanation for the observed relationship between the estimated rate and the depth of the calibration. We rule out the possibility that it is a spurious result arising from sequence errors, and find it unlikely that the apparent decline in rates over time is caused by mutational saturation. Using a rate curve estimated from the d-loop data, several dates for last common ancestors were calculated: modern humans and Neandertals (354 ka; 222-705 ka), Neandertals (108 ka; 70-156 ka), and modern humans (76 ka; 47-110 ka). If the rate curve for a particular taxonomic group can be accurately estimated, it can be a useful tool for correcting divergence date estimates by taking the rate decay into account. Our results show that it is invalid to extrapolate molecular rates of change across different evolutionary timescales, which has important consequences for studies of populations, domestication, conservation genetics, and human evolution. PMID: 15814826 [PubMed - indexed for MEDLINE] |
Guest IP-штамп: fr45uHVgO7WZ2 гость |
Review: 1 [Click to change filter selection through My NCBI.] 1: Trends Genet. 2006 Feb;22(2):79-83. Epub 2005 Dec 13.Click here to read Links Molecular clocks: when times are a-changin'. Ho SY, Larson G. Department of Zoology, University of Oxford, Oxford OX1 3PS, UK. The molecular clock has proved to be extremely valuable in placing timescales on evolutionary events that would otherwise be difficult to date. However, debate has arisen about the considerable disparities between molecular and palaeontological or archaeological dates, and about the remarkably high mutation rates inferred in pedigree studies. We argue that these debates can be largely resolved by reference to the "time dependency of molecular rates", a recent hypothesis positing that short-term mutation rates and long-term substitution rates are related by a monotonic decline from the former to the latter. Accordingly, the extrapolation of rates across different timescales will result in invalid date estimates. We examine the impact of this hypothesis with respect to various fields, including human evolution, animal domestication and conservation genetics. We conclude that many studies involving recent divergence events will need to be reconsidered. PMID: 16356585 [PubMed - indexed for MEDLINE] |
Guest IP-штамп: fr45uHVgO7WZ2 гость |
Review: 0 [Click to change filter selection through My NCBI.] 1: Mol Biol Evol. 2006 Sep;23(9):1731-40. Epub 2006 Jun 14.Click here to read Links A mitogenomic timescale for birds detects variable phylogenetic rates of molecular evolution and refutes the standard molecular clock. Pereira SL, Baker AJ. Department of Natural History, Royal Ontario Museum, Toronto, Ontario, Canada. sergio.pereira@utoronto.ca Current understanding of the diversification of birds is hindered by their incomplete fossil record and uncertainty in phylogenetic relationships and phylogenetic rates of molecular evolution. Here we performed the first comprehensive analysis of mitogenomic data of 48 vertebrates, including 35 birds, to derive a Bayesian timescale for avian evolution and to estimate rates of DNA evolution. Our approach used multiple fossil time constraints scattered throughout the phylogenetic tree and accounts for uncertainties in time constraints, branch lengths, and heterogeneity of rates of DNA evolution. We estimated that the major vertebrate lineages originated in the Permian; the 95% credible intervals of our estimated ages of the origin of archosaurs (258 MYA), the amniote-amphibian split (356 MYA), and the archosaur-lizard divergence (278 MYA) bracket estimates from the fossil record. The origin of modern orders of birds was estimated to have occurred throughout the Cretaceous beginning about 139 MYA, arguing against a cataclysmic extinction of lineages at the Cretaceous/Tertiary boundary. We identified fossils that are useful as time constraints within vertebrates. Our timescale reveals that rates of molecular evolution vary across genes and among taxa through time, thereby refuting the widely used mitogenomic or cytochrome b molecular clock in birds. Moreover, the 5-Myr divergence time assumed between 2 genera of geese (Branta and Anser) to originally calibrate the standard mitochondrial clock rate of 0.01 substitutions per site per lineage per Myr (s/s/l/Myr) in birds was shown to be underestimated by about 9.5 Myr. Phylogenetic rates in birds vary between 0.0009 and 0.012 s/s/l/Myr, indicating that many phylogenetic splits among avian taxa also have been underestimated and need to be revised. We found no support for the hypothesis that the molecular clock in birds "ticks" according to a constant rate of substitution per unit of mass-specific metabolic energy rather than per unit of time, as recently suggested. Our analysis advances knowledge of rates of DNA evolution across birds and other vertebrates and will, therefore, aid comparative biology studies that seek to infer the origin and timing of major adaptive shifts in vertebrates. |
Monstera Участник Томск |
(Guest1 @ 24.09.2007 07:38) зависит ли хвр-1 от жителей в екологически грязных раёнах + мутагены в продуктах питания по сравнению с благополучными раэнами ? Вроде как маленько зависит. Посмотрите тут: |
nigoal123 IP-штамп: fr/1ZkUsuBQOE гость |
and technical language to help |
« Предыдущая тема · Молекулярная и клеточная биология · Следующая тема » |