| |||
|
Литература » Биология » всего: 3088 страницы (155): < 1 2 3 4 5 6 > » A user's guide to the human genome; Nature Genetics supplement Tyra G Wolfsberg, Kris A Wetterstrand, Mark S Guyer, Francis S Collins & Andreas D Baxevanis Nature Publishing Group/Macmillan Online Publishing; 2002; pp82 The primary aim of A User’s Guide to the Human Genome is to provide the reader with an elementary hands-on guide for browsing and analyzing data produced by the International Human Genome Sequencing Consortium and other systematic sequencing efforts. The majority of this supplement is devoted to a series of worked examples, providing an overview of the types of data available, details on how these data can be browsed, and stepby- step instructions for using many of the most commonly-used tools for sequence-based discovery. The major web portals featured throughout include the National Center for Biotechnology Information Map Viewer, the University of California, Santa Cruz Genome Browser, and the European Bioinformatics Institute’s Ensembl system, along with many others that are discussed in the individual examples. It is hoped that readers will become more familiar with these resources, allowing them to apply the strategies used in the examples to advance their own research programs. A user's guide to the human genome; Nature Genetics supplement Tyra G Wolfsberg, Kris A Wetterstrand, Mark S Guyer, Francis S Collins & Andreas D Baxevanis Nature Publishing Group/Macmillan Online Publishing; 2002; pp82 http://rapidshare.de/files/3544342/A_user_...genome.pdf.html Wolfsberg T.G., Wetterstrand K.A., Guyer M.S., Collins F.S., Baxevanis Nature Publishing Group/Macmillan Online Publishing; 2002; 82стр. The primary aim of A User’s Guide to the Human Genome is to provide the reader with an elementary hands-on guide for browsing and analyzing data produced by the International Human Genome Sequencing Consortium and other systematic sequencing efforts. The majority of this supplement is devoted to a series of worked examples, providing an overview of the types of data available, details on how these data can be browsed, and stepby- step instructions for using many of the most commonly-used tools for sequence-based discovery. The major web portals featured throughout include the National Center for Biotechnology Information Map Viewer, the University of California, Santa Cruz Genome Browser, and the European Bioinformatics Institute’s Ensembl system, along with many others that are discussed in the individual examples. It is hoped that readers will become more familiar with these resources, allowing them to apply the strategies used in the examples to advance their own research programs. Ред. Provan D. BMJ Publishing Group; 2003; 88стр.; ISBN: 0727916769 This short volume includes chapters on all areas of haematology written by people who deal with these diseases on a daily basis. The book provides descriptions of these diseases and describes the pathways involved in diagnosis and treatment. Full colour is used throughout and the book is heavily illustrated, using clinical material and text boxes to emphasise key points. The book attempts to provide a practical up-to-date guide of our current state of knowledge in this fast-moving area. Jargon is kept to a minimum so that the text does not require extensive prior knowledge. Kingston H.M. BMJ Publishing Group; 2002; 126стр.; ISBN: 0727916270 This ABC is a concise, highly illustrated introduction to genetic mechanisms involved in inherited disorders. The book has been extensively updated with new and revised chapters to encompass rapid advances in the field. Basic genetic concepts are explained along with the application of new technologies in clinical practice. Information on relevant websites is also included along with recommended texts for further reading. Barrow C.J., Small D.H. Springer-Verlag; 2006; 300стр.; ISBN: 1852339616 Book Description Recent advances in genetics and brain biochemistry point to the Abeta peptide as the major culprit in causing neurodegeneration in Alzheimers Disease (AD). Abeta Peptide and Alzheimers Disease is specifically targeted at summarizing current knowledge of the Abeta peptide and its role in AD. Written by leaders in the industrial and academic world specializing in this rapidly moving area, the book covers fundamental biochemical studies on this peptide, the genetic impact on Abeta expression and processing, and various AD therapeutic strategies that target Abeta. Although specifically focusing on the Abeta peptide and AD, there is also some discussion on the similarity and differences of this peptide and AD with other amyloidogenic diseases, such as prion disease, Parkinsons and Huntingtons. This book will primarily be of interest to AD researchers and clinicians but also to researchers of other amyloid diseases. Reilly P.R. Cold Spring Harbor Laboratory Press; 2000; 339стр.; ISBN: 0879695803 Twenty-four true, wide-ranging tales of crime, history, human behavior, illness, and ethics, told from the personal perspective of the author, an eminent physician-lawyer who uses the stories to illustrate the principles of human genetics and to discuss the broader issues. Avdeef A. 2003; 312стр.; ISBN: 0471423653 Review “...a useful book for anyone interested in the measurement of physiochemical parameters that relate to drug permeability.”(Journal of Medicinal Chemistry, Vol. 47, No. 7) "...useful compilations of data...of use to those working in the agrochemical and environmental industries..." (Chemistry & Industry, 19 January 2004) Review “...a useful book for anyone interested in the measurement of physiochemical parameters that relate to drug permeability.”(Journal of Medicinal Chemistry, Vol. 47, No. 7) "...useful compilations of data...of use to those working in the agrochemical and environmental industries..." (Chemistry & Industry, 19 January 2004) [b] http://rapidshare.de/files/3544416/Absorpt...opment.pdf.html Avdeef A. John Wiley & Sons; 2003; 312стр.; ISBN: 0471423653 Of the hundreds of thousands of compounds synthesized each year, most have almost no chance of becoming drugs. This problem exists because most molecules lack eht drug-like poperties necessary to enable them to be effective in vivo. To address this issue, Alex Avdeef’s Absorption and Drug Development shows the reader how to examine a compound’s pharmaceutical properties, emphasizing oral absorption. This book explains the different physiochemical methods currently used to analyze drug candidates and how to interpret these methods. Topics discussed include:
Also included are physicochemical data for over 200 commercial drugs. With over 600 references and 100 drawings, this book is suitable for the practical pharmaceutical chemist and those seeking a better understanding of physiochemical measurements. Brimblecombe P., Hara H., Houle D., Novak M. Springer-Verlag; 2007; 420стр.; ISBN: 1402058845 Book Description Acid rain is still with us. Although it is a problem that people have worked diligently to solve, there are still many problem areas throughout the world. In reality the focus of acid rain research has shifted, and this book adds new vision to the topic. It contains papers, selected from Acid Rain 2005, the 7th International Conference on Acid Deposition, that take a broad perspective of the issues, emphasizing a number of themes: - the emission, concentration and deposition of pollutants - nitrogen and trace elements in ecosystems and their effects on forests, water and soil - studies of material damage and recovery - critical loads The book is aimed at scientists and researchers who are working in the area of acid rain and its effects, and on nutrient cycling. This latest research will be of value to those concerned with the mitigation of acid rain effects. Ред. Valentine J.S., Foote C., Greenberg A., Liebman J.F. Springer-Verlag; 1995; 481стр.; ISBN: 0751403725 Book Description The chemistry and biochemistry of oxygen has become a very active area of research in recent years. There is interest in the subject from fields ranging from medicine to biology and chemistry to engineering and environmental studies. These volumes provide an introduction to the field suitable for first year graduate students with a bachelor's degree in virtually any science and also for practicing professionals with no background in this area. There is no previous treatment at this level. The properties and reactions of oxygen in chemical and biochemical systems are described in enzymatic, environmental, organic, and inorganic systems. There are significant medical applications of this area of research, for example, in white cell antimicrobial activity, ALS, ischemia, cardiovascular disease, dietary antioxidants, cancer, and ageing. This book should be of interest to researchers and students of organic, bioorganic, bioinorganic chemistry and biochemistry. Book Info Explores the active research area of the chemistry and biochemistry of oxygen. Surveys oxidation activation in key biological systems. Ред. Foote C.S. Blackie Academic & Professional; 1995; 342стр.; ISBN: 0751402923 Book Description Taking an interdisciplinary approach, this book and its counterpart, Active Oxygen in Biochemistry, explore the active research area of the chemistry and biochemistry of oxygen. Complementary but independent, the two volumes integrate subject areas including medicine, biology, chemistry, engineering, and environmental studies. Book Info Explores the active research area of the chemistry and biochemistry of oxygen. Surveys oxidation activation in key biological systems. Ред. Foote C., Valentine J.S., Greenberg A., Liebman J.F. Springer-Verlag; 1995; 360стр.; ISBN: 0412034417 Book Description Taking an interdisciplinary approach, this book and its counterpart, Active Oxygen in Biochemistry, explore the active research area of the chemistry and biochemistry of oxygen. Complementary but independent, the two volumes integrate subject areas including medicine, biology, chemistry, engineering, and environmental studies. Book Info Explores the active research area of the chemistry and biochemistry of oxygen. Surveys oxidation activation in key biological systems. --This text refers to the Hardcover edition. Drugs and the Pharmaceutical Sciences Nusim S. Marcel Dekker, Inc.; 2005; 368стр.; ISBN: 082470293X Book Description Focusing on the three most critical components that successfully bring an API to market-process development, manufacturing, and governmental regulation and approval-this reference serves as a step-by-step guide to the planning and clear understanding of the bulk manufacturing of APIs. It offers current and timely discussions of the process development cycle, design engineering, the approval process, quality control and assurance, and validation, as well as plant manufacturing activities including materials management, maintenance, and safety. Filling a gap in the literature, this guide covers all the essential information required to effectively plan and execute manufacturing APIs. To buy: Current Topics in Microbiology and Immunology кн.313 Pandolfi P.P., Vogt P.K. Springer-Verlag; 2007; 276стр.; ISBN: 3540345922 Book Description Over the past 10 years, work on acute promyelocytic leukemia (APL) has become the paradigm of translational research that began with the discovery of a recurrent chromosomal translocation, followed by the identification of the genes and proteins involved, finding their molecular functions in transcriptional control, establishing mouse models and culminating in the development of targeted therapy. Methods in Molecular Medicine кн.21 Ред. Wold W.S. Humana Press; 1998; 368стр.; ISBN: 0896035514 A cutting-edge collection of readily reproducible methods for conducting research with adenoviruses, the premier and most widely used model in cell and molecular biology. The methods range from how to grow and titer adenoviruses and how to construct specific alterations in the adenovirus genome, to how to measure apoptosis induced by cells of the immune system, cytokines, and intrinsic apoptosis effectors. In addition, there are methods to study transcription and splicing with in vitro systems and for the adenovirus-mediated transformation of cells to a malignant state. Each method is written by a prominent investigator well-versed in the technique and includes a brief background discussion and tried, as well as true step-by-step instructions. Methods in Molecular Medicine кн.130 Wold W.S., Tollefson A.E. Humana Press; 2007; 241стр.; ISBN: 1588295982 Review Reviews of the First edition: "This book caters quite well to those who simply want to grow adenoviruses, assay them, and use them. . .a very comprehensive methods book that will be a laboratory standard for years to come."-Microbiology Today ". . .this book constitutes an excellent reference text . . .this book is replete with useful information for both the virologist and the non-virologist who is interested in working with adenoviruses."-FEBS Letters Book Description Adenovirus Methods and Protocols, Second Edition, now in two volumes, is an essential resource for adenovirus (Ad) researchers beginning in the field, and an inspirational starting point for researchers looking to branch into new areas of Ad study. In addition to updating and expanding important chapters from the first edition, the authors have added new chapters that address innovative, exciting areas of emphasis in Ad research, including Ad vector construction and use, real-time PCR, use of new animal models, and methods for quantification of Ad virus or virus expression/interactions. Each of the protocols presented in these volumes is written by trendsetting researchers in their respective areas of expertise. Volume 1 addresses several important techniques for construction of adenoviruses for use as vectors and for basic research. Highlighted topics include deletion mutants, capsid modifications, insertions, and gene replacements in human, murine, bovine, and ovine adenoviruses. In Volume 2, the authors focus on methods that elucidate and quantitate the interactions of Ad with the host. Each of the protocols in these volumes provides a general introduction, followed by tried-and-true step-by-step methods. Both novice and experienced researchers will reap tremendous benefit from these groundbreaking volumes in Ad research. Methods in Molecular Medicine кн.131 Wold W.S., Tollefson A.E. Humana Press; 2007; 362стр.; ISBN: 1588299015 Review Reviews of the First edition: "This book caters quite well to those who simply want to grow adenoviruses, assay them, and use them. . .a very comprehensive methods book that will be a laboratory standard for years to come."- Microbiology Today ". . .this book constitutes an excellent reference text . . .this book is replete with useful information for both the virologist and the non-virologist who is interested in working with adenoviruses."-FEBS Letters Book Description Adenovirus Methods and Protocols, Second Edition, now in two volumes, is an essential resource for adenovirus (Ad) researchers beginning in the field, and an inspirational starting point for researchers looking to branch into new areas of Ad study. In addition to updating and expanding important chapters from the first edition, the authors have added new chapters that address innovative, exciting areas of emphasis in Ad research, including Ad vector construction and use, real-time PCR, use of new animal models, and methods for quantification of Ad virus or virus expression/interactions. Each of the protocols presented in these volumes is written by trendsetting researchers in their respective areas of expertise. Volume 1 addresses several important techniques for construction of adenoviruses for use as vectors and for basic research. Highlighted topics include deletion mutants, capsid modifications, insertions, and gene replacements in human, murine, bovine, and ovine adenoviruses. In Volume 2, the authors focus on methods that elucidate and quantitate the interactions of Ad with the host. Each of the protocols in these volumes provides a general introduction, followed by tried-and-true step-by-step methods. Both novice and experienced researchers will reap tremendous benefit from these groundbreaking volumes in Ad research. Medical Intelligence Unit кн.15 Seth P. Landes - R.G. Landes Company; 1999; 314стр.; ISBN: 1570595844 Landes Bioscience produces books in six Intelligence Unit series: Medical, Molecular Biology, Neuroscience, Tissue Engineering, Biotechnology and Environmental. The authors of our books are acknowledged leaders in their fields. Topics are unique; almost without exception, no similar books exist on these topics. Our goal is to publish books in important and rapidly changing areas of bioscience for sophisticated researchers and clinicians. To achieve this goal, we have accelerated our publishing program to conform to the fast pace at which information grows in bioscience. Most of our books are published within 90 to 120 days of receipt of the manuscript. We would like to thank our readers for their continuing interest and welcome any comments or suggestions they may have for future books. Progress in Inflammation Research Ред. Ley K. 2007; 309стр.; ISBN: 376437974X Product Description Inflammatory cell recruitment requires the concerted action of at least five major sets of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate structures serving as selectin ligands, and certain ectoenzymes. This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders in the field and focus on the biology, structure, function, and regulation of adhesion molecules. Currently approved adhesion molecule-based therapies are reviewed and an outlook for future approaches is also provided. The book is of interest to clinicians and scientists from immunology, physiology, cancer research, rheumatology, allergology, infectious diseases, gastroenterology, pulmonology and cardiology. Methods in Molecular Biology кн.96 Ред. Dejana E., Corada M. Humana Press; 1999; 240стр.; ISBN: 0896032589 An international corps of expert investigators describe their optimized techniques for both the identification of new cell adhesion proteins and for the characterization of novel adhesive structures. Their cutting edge methods will enable both novice and experienced researchers readily to identify and clone new adhesion proteins, to successfully produce inhibitors of the adhesive activity, to develop biological models for the assay of cell-to-matrix and cell-to-cell adhesion in vitro, and to measure the signaling activities of adhesion proteins. By illuminating these adhesive molecules and the possibilities for manipulating them, the new experimental strategies collected here will have considerable clinical potential for the regulation of immunity, inflammation, tissue remodeling, and embryonic development. |
|