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 ! slavak4609




  18.03.2014 17:22                   e-mail

: LSCC.gif 3q26, PRKCI SOX2. . Hh, .

- . (lung squamous cell carcinoma - LSCC) 30% . LSCC , , . LSCC 3q26, - PRKCI SOX2, , .

LSCC 3q26 . , SOX2, . , .

- , PRKCI PKCi. PKCi . PKCi Hh (Hedgehog), , , . Hh , .

, PKCi SOX2 HHAT GLI1 Hh. SOX2 PKCi HHAT. HHAT , SHH, PTCH1, SMO Hh.

, , PRKCI SOX2, LSCC. LSCC , Hh, .


:
Justilien V, Walsh MP, Ali SA, Thompson EA, Murray NR, FieldsAP. The PRKCI and SOX2 Oncogenes Are Coamplified and Cooperate to Activate Hedgehog Signaling in Lung Squamous Cell Carcinoma. // Cancer Cell. 2014; V. 25: P. 139-151.


   : :    , ": "
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