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Our PhD and MS Degree programs are open to talented students from all over the globe. Qualified candidate students receive financial support from various scholarship sources during the course of their study (4 yr for PhD, 3 yr for MS). Please check out the following links for more information. Information about financial support and application procedure can be found at Ming Yu, Ph.D., Professor Transcription is the first step of gene expression, and is critical for the survival, development and metabolism of all organisms. Transcription factors (TFs) are chromatin-binding proteins that are capable of modulating the rate of transcription. It is known that more than 50% human cancers are caused by mutations of TFs, and more than 50% of the SNPs discovered by GWAS are in close proximity of TF binding sites. Our laboratory is interested in understanding the molecular mechanisms of transcriptional regulation in human cells and how transcriptional dysregulations cause disease. Mainly taking proteomic, genomic, bioinformatic and genetic approaches, we are currently focusing on understanding roles of the PAF1C complex (PAF1C) and the super elongation complex (SEC) in transcriptional elongation and mixed lineage leukemia (MLL), the most common childhood leukemia in North America. Our work will advance current understanding of transcriptional regulation and lay the foundation for the development of targeted therapy against MLL. Highly motivated candidates with undergraduate degrees related to biology are encouraged to apply to the Ph.D. and M.S. programs. Файл/ы:
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