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Xeno PVS IP-штамп: frazJweWU8l1s гость |
1) Phosphorylation signals generated as a result of integrin ligation regulate cellular events such as the assembly and disassembly of focal adhesions, and reorganization of the actin cytoskeleton. 2) A constitutively active variant of c-Src, v-Src, has been observed to induce disruption of the actin cytoskeleton, loss of focal adhesions, and impaired deposition of fibronectin matrix. 3) The deposition is a cell-dependent event initiated with binding of soluble fibronectin to cell surface integrins in vinculin-containing focal adhesions. 4) Fibronectin deposition requires intact focal adhesions, which in turn serve as anchors for actin stress fibers involved in cell locomotion. Огромное спасибо!!! |