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  02.04.2014 07:47                   e-mail

: AML.gif (acute myeloid leukaemia AML) (haematopoietic stem cells HSCs) DNMT3A (DNMT3Amut), NPM1. HSCs HSCs, . AML.

. . AML , , . . AML .

(~250 ) 103 , - AML. AML - (DNMT3Amut) ARF/p53 NPM1 (NPM1). - NPM1 .

( 12 ) , DNMT3Amut. NPM1 . AML .

DNMT3Amut , . DNMT3Amut, NPM1. DNMT3Amut. , AML, , DNMT3Amut. HSCs. DNMT3Amut. . , - AML HSCs, DNMT3Amut. , .

, - HSCs HSCs .

, DNMT3A HSCs AML. AML NPM1 (NPM1), .

. HSCs, , AML. , - HSCs, . , DNMT3A . AML .


: Shlush LI, Zandi S, Mitchell A, Chen WC, Brandwein JM, Gupta V, Kennedy JA, Schimmer AD, Schuh AC, Yee KW, McLeod JL, Doedens M, Medeiros JJ, Marke R, Kim HJ, Lee K, McPherson JD, Hudson TJ; HALT Pan-Leukemia Gene Panel Consortium, Brown AM, Trinh QM Stein LD, Minden MD, Wang JC, Dick JE. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. // Nature. 2014; V. 506: P. 328-333.


: (%) DNMT3Amut NPM1 (AML) - AML. 0-100 .


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