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: Rb vs YAP

Pages: 1, 2, 3, 4, 5, 6
xenopus, 11.08.2014 21:39
: Organ_Size_Control_Is_Dominant_over_Rb_Family_Inactivation.jpg Rb ( Retinoblastoma) , G0 G1. E2F, . Rb . , Rb . , , "" Rb , .

Cell Reports Rb . , . , , . Rb Rb, p107 p130 (TKO, triple-knockout). , TKO ( ) . , Rb . , p53-, E2F. "" TKO , , TKO-, YAP. YAP , Hippo, , . YAP TEAD1, YAP. , E2F YAP -. TKO- - YAP - E2F . ; , E2F YAP -.

, Rb. Hippo- , .

:
Ehmer et al. Organ Size Control Is Dominant over Rb Family Inactivation to Restrict Proliferation In Vivo. Cell Rep. 2014 Jul 24;8(2):371-81.
graphical abstract .
.
Guest, 29.08.2014 10:41
http://en.wikipedia.org/wiki/E2F
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Guest, 29.08.2014 11:24
"YAP " ©

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Guest, 29.08.2014 11:30
(Guest @ 29.08.2014 11:24)
   "YAP "

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http://www.nature.com/nm/journal/v20/n6/full/nm.3562.html
Guest, 29.08.2014 13:22
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- 2000

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Guest, 29.08.2014 13:32
- YAP , E2F

Mouse modENCODE smile.gif
Guest, 29.08.2014 14:16
" ; , 2 -." () smile.gif

- YAP -
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Guest, 29.08.2014 14:24
(Guest @ 29.08.2014 14:16)
   " ; , 2 -." () smile.gif

-   YAP              -
      MEME-CHIP                  - smile.gif

http://www.ncbi.nlm.nih.gov/pmc/articles/P...6-8935-6-30.pdf
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Guest, 29.08.2014 14:37
(Guest @ 29.08.2014 13:22)
   smile.gif

- 2000

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http://www.nature.com/nprot/journal/v8/n9/...t.2013.099.html
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