We are proud to invite you to Skoltech Colloquium!
Guest Speaker: Anton Berns, Ph.D Professor, Skoltech Centre for Stem Cell Research, Moscow & The Netherlands Cancer Institute, Amsterdam.
When: October 31; 4:00pm
Where: Institute of Gene Biology RAS, ul. Vavilova 34/5, Conference room, 1st floor.
What: Mouse models of cancer: cells-of-origin of small cell and non-small cell lung cancer.
Abstract: Small cell lung cancer (SCLC) is one of the most lethal human malignancies, due to its high metastatic potential and chemo-resistance upon relapse. Using the Rbf/f;p53f/f mouse model for SCLC, we found that the tumors are often composed of phenotypically different cells, characterized by mesenchymal and neuroendocrine markers. These cells often share a common origin. Crosstalk between these cells can endow the neuroendocrine component with metastatic capacity, illustrating the potential relevance of tumor cell heterogeneity in dictating functional tumor properties. Also specific genetic lesions appear to be associated with metastatic potential. Interestingly, the two cell types can also interconvert raising the question of their cell-of-origin. To investigate this in more detail, we inactivated Trp53 and Rb1 in distinct cell types in the adult lung by targeting Cre-recombinase expression to Clara, neuroendocrine, and alveolar type II cells using adenoviral vectors. We could show that neuroendocrine cells serve as the predominant although not the exclusive cell of origin of SCLC.
In contrast, mutant Kras-driven adenocarcinomas (one of the NSCLC subtypes) originates primarily from alveolar type II cells. However, in LSL-mutant-Kras;p53flox/flox mice also other cell types gave effectively rise to adenomas and adenocarcinomas. Our data indicate that both cell type specific features and the nature of the oncogenic lesion(s) are critical factors in determining the tumor initiating capacity of lung (progenitor) cells. Furthermore, the cell-of-origin appears to influence the properties of the resulting tumors.
If you would like to participate and for further information or questions, please e-mail Alesya Garifullina - firstname.lastname@example.org
- Do you need to predict tree pests & diseases for planning, investment, monitoring?
- Do you need reliable models with assumptions and outputs that you recognize?
- Do you need information on invasive forest pests & pathogens under climate change?
This workshop introduces models to predict the spread of invasive pests and diseases that have been developed and tested over three years through the collaboration of pathologists, entomologists and mathematical modellers in ISEFOR*. Model developers will demonstrate and explain the structure of the models: inputs, outputs and rules. You will have time for discussion about assumptions and describe your first impressions of the predictive facility of the models. You will work with the models, get to know them and derive your own output. The 8-hour workshop is programmed over two days to allow informal time for you to discuss model predictions and your needs with ISEFOR researchers and colleagues.
Contact Colette Jones to book your place at the workshop email@example.com
This is the final workshop from the ISEFOR research project 2010-2014. ISEFOR researchers have worked together over three years analysing threats to European forests from invasive pests and pathogens, including alien organisms, vulnerable hosts, trade pathways for disease spread and the use of sentinel tree nurseries in China. More information is available at http://www.isefor.com/
*ISEFOR is a consortium of researchers funded by European Union Seventh Framework Programme
FP7 2007-2013 KBBE 2009-3 under grant agreement 245268; project coordinator Professor Stephen Woodward; administrator Dr Colette Jones firstname.lastname@example.org
Modelling invasive pests & disease in European forests Workshop 19th-20th Feb 2014
Cellular automaton (CA) modelling
The workshop presents models developed by Prof Timo Pukkala and Timo Möykkynen at the
University of Eastern Finland. These are cellular automata models (CA), used commonly to simulate
the spread of forest fires and city expansion. CA models are cell-based with temporal and spatial
aspects. Every cell has a discrete state that depends on the states of neighbouring cells. States are
updated in discrete time steps according to fixed rules.
Selection of pests and diseases in ISEFOR
The disease-causing species that are modelled in ISEFOR were selected because: they are invasive; cause serious damage; environmental requirements are known; occurrence maps of host species are available; show a range of spread mechanisms; they permit different CA model variants and each can be used for other species with similar spread mechanisms. Models completed include: Pinewood nematode Bursaphelenchus xylophilus; Ash dieback, Chalara fraxinea; Pine pitch canker, Fusarium circinatum; Dothistroma needle blight, Dothistroma septosporum; Siberian moth Dendrolimus sibiricus; Emerald ash borer, Agrilus planipennis; Alder phytophtora The biology
Modellers work closely in ISEFOR with experts on the biology of the pest or pathogen: Christelle
Robinet INRA; Thomas Kirisits BOKU; Jan Stenlid SLU; Andrea Vannini and AnnaMaria Vettraino
UNITUS; Alberto Santini IPP-CNR; Stephen Woodward UOAberdeen; Paolo Capretti UoFirenze.
Model inputs, rules and parameters
Knowledge of pest and pathogen spread, host species cover, entry points and climatic variables are incorporated in the models via inputs and rules and determine cell states and transitions.
Model outputs include raster maps of forests, infected trees per cell, years of infection, probability of infection; area and percentage of infected cells; temporal development of infection.
Day 1 Wednesday 19th February
Register from 11:15am onwards 1pm Welcome and buffet lunch 2pm Explanation of the models (7 models) How they work and results from each model 3:30pm Break 4pm Working with the models. In working groups, each group uses one model 5:30pm Question and answers from Day 1 7pm Dinner
Day 2 Thursday 20th February
8:30am Concluding sessions: Groups present their results 9:15am The models and the results are discussed 10:30am Break 11am Overall discussion on modelling invasive pests and pathogens 1pm workshop end delegates prepare to depart
We are proud to invite you to Skoltech Colloquium!
Guest Speaker: Alexander B. Chetverin.
He received his Master, Ph.D., and D.Sc. degrees in molecular biology from the Lomonosov Moscow State University. From 1990 to 1992, he has been a Visiting Investigator at the Public Health Research Institute, New York. In 1997, he was elected Corresponding Member of the Russian Academy of Sciences. He invented the method of molecular colonies in collaboration with his wife Helena V. Chetverina in late eighties.
When: October 17; 4:00pm
Where: Moscow, Institute of Gene Biology RAS, ul. Vavilova 34/5, Conference room, 1st floor.
What: Early and reliable diagnosis of deadly diseases with molecular colonies
Abstract: Many deadly diseases, such as AIDS, cancer, and tuberculosis, are accompanied by the appearance in the patient’s body of particular nucleic acid (DNA or RNA) molecules that can serve as molecular diagnostic markers. The earlier a marker is revealed, the higher are the patient’s chances for survival and the easier can the disease be prevented from spreading. Detecting small amounts of DNA or RNA molecules is only possible after amplifying them, usually by PCR (polymerase chain reaction). However, due to limited amplification specificity, the sensitivity of even the most advanced assays is still insufficient for timely diagnosis, with the rate of false-positive and false-negative results being too high. The problem can be overcome by carrying out the amplification reaction in a gel film, rather than in a test tube. In this format, the amplification products become entrapped in the gel matrix and accumulate around the progenitor molecule, resulting in a 2-D pattern of molecular colonies. Each colony comprises a molecular clone, the progeny of a single starting DNA or RNA template. This provides for the detection, enumeration, and analysis of single molecules present in the analyzed sample. The molecular colony format eliminates the competition from concurrently amplifying non-target nucleic acids and makes the assay digital, as the signal from a colony only needs to be detected without measuring its intensity. This greatly increases the reliability of diagnostics and permits the titer of a molecular marker to be directly determined by counting the number of specific colonies.
Further Information If you would like to participate and for further information or questions, please e-mail Alesya Garifullina - email@example.com
International healthcare leader Novartis opens a unique opportunity for top students from Russia to take part in International Novartis Biocamp Forum2013.The Novartis International Biotechnology Leadership Camp (BioCamp) is a three day seminar that brings the biotechnology sector closer to talented students from top universities around the world.
If you are: - Student/Post-graduate in biotechnology, natural science or medicine - Fluent in English - Interested in biotechnology/pharmaceutical sector - Able to join this program from 25-28 August 2013 You are welcome to submit your CV and motivation letter (why I want to be in Biocamp 2013) to Anna Sanina on e-mail: firstname.lastname@example.org with subject: Novartis Biocamp2013. Please note: deadline for applications is 23rd of May 2013.
Dear colleagues! IVM Symposium is the world’s only event dedicated solely to in vivo two-photon (multiphoton) imaging, a revolutionary technique that combines high resolution (in the nanometer scale) with high relevance that comes from imaging inside the living organisms. Last year’s event received raving reviews. We shall keep the old format combining lectures, practical training and a small exhibition. This year’s impressive line-up of new speakers includes: Alberto Diaspro Italian Institute of Technology/University of Genoa Olga Garaschuk University of Tuebengen, Germany Elizabeth Hillman Columbia University, New York, USA Mark Huebener Max Planck Institute of Neurobiology, Germany Chester Mathis University of Pittsburgh, USA
Apply now for the 2013 Summer Institute on Aging Research
February 4, 2013 Applications are now open to participate in the National Institute on Aging (NIA) 2013 Summer Institute on Aging Research. This 6-day workshop for investigators new to the field is focused on current issues, research methodologies, and funding opportunities. The Summer Institute, one of the premier short-term training opportunities for new investigators, is scheduled to be held July 14-19, 2013 in Bethesda, Maryland, on the campus of the National Institutes of Health. Support is available for travel and living expenses. Applications are due March 22, 2013.
Read more and view videos of 2012 Summer Institute participants
Offered through the NIA Office of Special Populations, investigators focusing on health disparities research are encouraged to apply. As with all NIH programs, investigators of diverse backgrounds are also encouraged to apply. Applicants must be U.S. citizens, non-citizen nationals or permanent residents. For additional information, contact Andrea Griffin-Mann at email@example.com.
MCCMB'13 (Moscow, Russia, July 25-28, 2013) is the sixth International Moscow Conference on Computational Molecular Biology and Bioinformatics.
We welcome submissions of two-page abstracts from researchers working, in particular, in the following areas: - Sequence analysis (statistics of DNA and protein sequences; functional annotation of genes, proteins and genomes); - Structure of biopolymers (prediction of protein structure; interaction of proteins with ligands; comparative analysis of protein 3D structures; prediction of RNA structure); - Molecular evolution (phylogenetic analysis; comparative genomics; genome rearrangements); - Omics (genome and metagenome analysis; transcriptomics; large-scale analysis of proteomes and protein-protein interactions); - Systems biology (metabolic and signal pathways; models and networks); - Next generation sequencing; - Bioalgorithms.
The Executive Committee of FEBS has awarded the FEBS Congress for 2013 to the Russian Biochemical Society. It will be located in St. Petersburg, July 6th – 11th 2013 under the Congress Presidency of Professor Vladimir Skulachev with Professor Sir Richard Roberts as Chairman of the International Advisory Board.
The Congress Theme is “Mechanisms in Biology” and we are seeking to build a powerful and diverse program to support this key theme. Symposia presently under consideration include: Immunology, RNA, Carbohydrate Biochemistry, Stem Cell Biology, Mechanisms of Proteolysis, Bacteriology, Bioinformatics, & Techniques of Biochemistry. A total of 37 symposia will be included in the program. We are expecting to have a strong cohort of keynote and symposium speakers from Europe, USA, Japan and other countries.
Registration fees are accepted from January 5, 2013.
In your private Area, you will be able to manage the submission and corrections of abstracts before April 15, 2013. Please note, that your abstract will only be published if your payment is verified before April 15, 2013.
Young Scientists Forum Start of online registration and abstract submission October 1, 2012 Registration and abstract submission deadline January 15, 2013 Announcement of YSF Fellowships Winners February 28, 2013
The world's largest data set on human genetic variation, the 1000 Genomes Project, is now available for free through Amazon Web Services. The arrangement with Amazon, spearheaded through the US National Institutes of Health, makes data from sequencing the genomes of more than 1,700 people accessible through Amazon's cloud. Any scientist with an internet connection will be able to access all 200 terabytes of the data set in the cloud, avoiding the need to acquire additional bandwidth or data storage capacity. “It's a very large amount of data,” says William Spooner, chief technology officer at Cambridge, UK–based Eagle Genomics, which provides bioinformatics services for mining genomics data. http://www.nature.com/nbt/journal/v30/n5/f...c_id=NBT-201205
START A CAREER IN HIV RESEARCH: THE INTERNATIONAL AIDS SOCIETY TOGETHER WITH THE U.S. NATIONAL INSTITUTES OF HEALTH, AND THE CENTERS FOR AIDS RESEARCH INVITES EARLY-STAGE INVESTIGATORS TO APPLY FOR AN HIV RESEARCH GRANT
The International AIDS Society (IAS), in partnership with the U.S. National Institutes of Health (NIH) and the NIH-supported Centers for AIDS Research (CFAR), launched a new round of the joint research grant programme, Creative and Novel Ideas in HIV Research (CNIHR).
The CNIHR programme supports projects intended to advance the scientific understanding of HIV by exploring new approaches to pressing scientific questions on such issues as the long-term survival of individuals with HIV infection, mechanisms behind establishment of viral reservoirs, new approaches for the prevention of HIV transmission, and innovative models of health care delivery. It is designed to promote innovative research and new ideas from early-stage investigators whose primary focus has previously been in fields of scientific inquiry other than HIV/AIDS. It aims at recruiting and training tomorrow’s leading HIV researchers from across many areas of science, whose work will benefit not only HIV, but other fields of research as well.
The first step of the competitive application process is open on the CNIHR website (www.cnihr.org) and will close on 17 October 2011. Applicants will be asked to complete a two-step process to assess the quality of their research projects. Awardees will be selected by mid-April 2012.
Successful applicants will be invited to the XIX International AIDS Conference (AIDS 2012), in Washington D.C. 22-27 July 2012, where they will be officially awarded. They will also have the opportunity to attend an HIV orientation seminar with leading experts and take part in a networking session during the conference.
For more information about this programme: CNIHR 2012 Round Announcement CNIHR grant website: www.cnihr.org
Information on 2010 awardees: www.iasociety.org/Default.aspx?pageId=381
16thCIMO WINTER SCHOOL "Building blocks of life: from biomaterials to living organisms"
12 - 17 March 2012, Finland
The Centre for International Mobility CIMO invites applications from Russian and Ukrainian postgraduate students for participation in the 16th Winter School organized during 12 - 17 March 2012 at Tvärminne zoological station of the University of Helsinki.
The goal of the Winter School is to enhance the mobility of young researchers and postgraduate students between Finland and the participating countries and to increase the cooperation between the universities. Before applying for participation in the 16th Winter School, the applicants are expected to contact one or more scientists/research group leaders at Finnish universities to discuss a possible project with them. Expression of interest by the Finnish host will be considered an advantage during the selection process.
Those Winter School participants who will be invited to Finland after the Winter School by Finnish research teams will be offered a scholarship from the CIMO Fellowship programme. The invited participants of the Winter School will be expected to come to work or study in Finland for 3 to 18 months. In 2011, the monthly amount of scholarship was 1200 euro.The Centre for International Mobility CIMO invites applications from Russian and Ukrainian postgraduate students for participation in the 16th Winter School organized during 12 - 17 March 2012 at Tvärminne zoological station of the University of Helsinki (http://luoto.tvarminne.helsinki.fi).
Those Winter School participants who will be invited to Finland after the Winter School by Finnish research teams will be offered a scholarship from the CIMO Fellowship programme. The invited participants of the Winter School will be expected to come to work or study in Finland for 3 to 18 months. In 2011, the monthly amount of scholarship was 1200 euro.
In the era of Plant Genomics the amount of DNA information of crops has increased enormously. As a consequence, more effective and reliable phenotyping data has become the bottleneck for modern genetic crop improvement. Therefore Plant Phenotyping has become a major field of research in plant breeding.
In order to meet the challenges of this very new and promising field of research new technologies such as greenhouse automation and plant imaging systems are needed.
The PhenoDays 2011 International Symposium exactly addresses the Phenotyping bottleneck by providing stimulating talks from internationally renowned keynote speakers from the seed industry, breeding institutes and academic breeding groups working in the Plant Phenotyping research area.
This will surely be a great opportunity for the researchers from all over the world to meet and exchange their ideas, approaches and results in Plant Phenotyping research.
Besides the interesting scientific presentations the PhenoDays will also offer the opportunity to participate in practical workshops at one of the biggest Plant Phenotyping Research Facilities in Europe: The PhenoFab in Wageningen only 10 min. from the conference venue Hof van Wageningen.
Science Careers is conducting a survey of postdoc supervisors to learn more about what makes for a successful postdoc experience and to explore industry trends. The overall results of this survey will be published in the 26 August 2011 issue of Science.
If you supervise postdocs, would you please help us by taking our survey, which takes about 20 to 25 minutes to complete? In return, we'll enter your name in a drawing for one of 10 $50 Amazon gift certificates. All individual survey responses will be kept strictly confidential.
Label and Label-Free Technologies in Synergy Webinar
You are invited to view our panel of experts on Wednesday, March 2, 2011, in a live, online educational seminar, "Label and Label-free Technologies in Synergy: Creating a Powerful Approach to Drug Discovery."
Date: Wednesday, March 2, 2011 Time: 12:00 noon ET; 9:00 a.m. PT; 5 p.m. GMT Duration: 1 hour Register now and submit your questions LIVE to the experts during the webinar! For more information and complimentary registration visit: www.sciencemag.org/webinar
Label-free technologies have gained wide acceptance in both academic research settings and in drug discovery laboratories in recent years. With the advent of faster and more accurate label-free technologies, and their pairing with traditional systems for labeled detection, the use of highly sensitive medium to high throughput cellular and biochemical assays in microplate format is now routinely possible. This advance offers scientists a fuller picture of their system under study and speeds the screening of compounds for drug discovery. This webinar will explore in depth the pros and cons of combining traditional label technologies with label-free assays, a so-called orthogonal approach.
During the webinar, our panelists will:
Provide an overview of the various label-free technologies available Discuss how label-free technologies can be applied in drug discovery research Share their experience using a combination of label-free and traditional labeled detection systems Answer questions from webinar viewers live and in real time. Register at: www.sciencemag.org/webinar
Produced by the Science/AAAS Business Office and sponsored by PerkinElmer.
We are pleased to invite you to attend the 4th International Symposium of Environmental Physiology of Ectotherms and Plants (ISEPEP4), to be held on JULY 18-22, 2011 in Rennes, FRANCE (http://isepep4.univ-rennes1.fr/news.php).
Preliminary list of topics that may be covered during the conference:
1. Low temperature biology of insects - Dormancy, Diapause and Cryptobiosis - Phenology - Rapid cold hardening, acclimation and acclimatisation - Metabolism - Chilling injury and subsequent recovery
2. Molecular aspects of cold and heat stress: 'Omics' studies in low temperature biology of ectotherms and plants - Antifreeze and ice active proteins - Chaperone/heat shock proteins - Transcriptomics - Proteomics - Metabolomics
4. Water relations: - Dehydration and anhydrobiosis - Ion balance during stress - Ice nucleation and antinucleation - Aquaporins - Osmotic and ionic relations
5. Environmental physiology in alpine and polar environments
OMICS Publishing Group is organizing "International Conference & Exhibition on Virology" will be held during 5-7 September 2011 Baltimore, USA. We have attempted to contact you earlier regarding the Conference and as we are aware of your busy schedule and your engagement in many other activities, we would like to take the pleasure of contacting you again regarding Virology-2011 Baltimore, USA. We would like to take the utmost pleasure in inviting you to this conference to discuss and analyze “Novel Therapeutic Strategies in Virology".
Virology-2011 is a specially designed cluster conference, which covers a wide range of critically important sessions in basic Virology research to Advances in Cancer, Agriculture, Veterinary and Clinical research studies.
Virology-2011 organizing committee anticipates over 1500 participants to attend this premier event
The conference topics include:
• Viral Genomics and Proteomics • HIV associated diseases • Advances in Gene therapy • Tumour virology and immunology • Antiviral vaccine development • Clinical viral diagnostics • Agriculture and Plant virology • Veterinary viral genomics and proteomics • Pediatric viral diseases • Regulatory and Economical Aspects in Virology
OMICS Publishing Group invites you to attend the World Congress on Biotechnology going to be held on 21-23 March 2011 Hyderabad, India. We welcome all the participants from across the world to take part in this premier event.